Medical Finding Tied to Delirium, Mortality Rate
December 16, 2013 — The Indiana University School of Medicine says a new research finding could change medical treatments, and survival rates, for delirium.
IU says its Center for Aging Research and researchers from the Regenstrief Institute have identified the first biomarker that appears to be linked to the duration of delirium. The finding was published this month in the International Journal of General Medicine.
The research team leader and Regenstreif Institute investigator, scientist Babar Ali Khan, M.D. of IU’s Center for Aging Research, led the study, and he says every day with delirium in an Intensive Care Unit is associated with a 10% increased likelihood of death, and so the team’s discovery of a protein associated with the length of delirium could bring treatment to diminish its duration and ultimately prevent it.
IU says it is estimated that each year more than 7-million people hospitalized in the United States suffer acute confusion and disorientation characteristic of delirium. Delirium in older adults is associated with increased probability of developing dementia and to a high death rate.
IU says the study was conducted in the medical and surgical ICUs of Eskanazi Health. Authors, in addition to Dr. Khan, are Mark O. Farber, Noll Campbell, Anthony Perkins, Nagendra K. Prasad, Siu L. Hui, Douglas K. Miller, Enrique Calvo-Ayala, John D. Buckley, Ruxandra Ionescu, Anantha Shekhar, E. Wesley Ely and Malaz A. Boustani. Drs. Campbell, Hui, Miller and Boustani are Regenstrief investigators and IU Center for Aging Research scientists.